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Thread: Co proxamol

  1. #1
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    Co proxamol

    MY G.P.
    has informed me that co proxamol tablets I have been on for at least 10 years he will not
    prescribe for me any more as these are the only pain killers that suit me and work where do I go
    any one got the same problem?

  2. #2
    Senior Member mikeydt1's Avatar
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    with you been on them so long it was wrong of your doctor to just stop them without at least tapering. you could end up with withdrawals. you need to speak with your practice about the situation a.s.a.p

    i was on Tramadol for a long time and coming off them was a real nightmare.

  3. #3
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    Your GP is probably stopping them due to the cost, which is now around £45 per 100 tablets. The massive price increase being since their removal from the Drug Tariff in October 2015.

    As these tablets are the only ones that suit you, have you asked if they can be continued on a 'named patient basis'?

    The answer to that question is probably going to be a NO from your GP, as they will not normally accept the risks of prescribing this restricted medication.

    What alternatives have you tried, and found to be unsatisfactory - and why?
    Has your GP made a referral to a Pain Management Clinic for specialist advice?

  4. #4
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    If you've been on them for 10 years, your body is getting used to them abd they will be less effective. Is the GP going to prescribe others meds? Over the last 10 years there will probably have been new drugs.

  5. #5
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    Co proxamol

    thanks for all your advice, have written to my doctor telling him of my concerns
    have also asked for the tablets on a named basis
    will keep you updated

  6. #6
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    just an update, had a heated talk with my doctor over the phone, I explained I could and most probably addicted am to co proxamol so he accepted this and has put me on 4 tabs a day for the next three months to see if I can reduce my dependency

  7. #7
    Senior Member Kodiak's Avatar
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    You do not state what strength of Co-proxamol you are on.

    I was on 30/500 and my Doctor (New Doctor) advised me that I would be better off them as he said that they were not much better than Paracetamol. He said he would gradually reduce the Strength over a few months.

    It went like this, Finished my month on 30/500 then the 1 month on 15/500, the next month on 8/500 and the last month on 4/500. Then I was off them completely and now I take just Paracetamol and to be quite honest I feel much better. There is also one great advantage, No More Constipation
    Deep into that darkness peering, long I stood there, wondering, fearing, doubting, dreaming dreams no mortal ever dared to dream before.
    Edgar Allen Poe

  8. #8
    If you have received Co-proxamol prescriptions since 2008 you would definitely have been on the ‘Named Patient Scheme’.

    • During 2005 all patients who were prescribed this drug were forced to trial all alternatives.
    • Many Patients couldn't tolerate the alternate drugs. (I was one of them)
    • Parliament accepted a flawed CSM call for evidence report which was presented by MHRA. The report had a response under 15%
    • This resulted with MHRA revoking the remaining 17 Licences for Co-proxamol at the end of 2007.
    • MHRA and Government accepted that a number of patients wouldn't be able to tolerate the alternate drugs and made a provision for the drug to be prescribed on a ‘Named Patient’ basis.
    • Between 2005 and 2008 I suffered two years of horrendous side effects and inadequate pain control.
    • The Majority of GP’s refused to prescribe Co-proxamol following the advice of their insurers and union (mine included). When he realised how distressed I had become because of the severe side effects I had to endure he eventually put me in touch with a GP within the practice who had continued to prescribe Co-proxamol.
    • Fortunately from 2008 I continued receive a regular supply under the ‘MHRA’s Named Patient Scheme’ this continued for over seven years.
    • Within four weeks of receiving a regular supply of Co-proxamol my gastrointestinal side effects had disappeared and a good level of pain control returned as well as a regular pattern of sleep.
    • During November 2015 CCGs informed their members to switch patients to alternative medication after fears that the annual spend would far outreach the £3.2 million spent in 2014 on Co-proxamol. This decision was based on financial savings NOT MEDICAL NEED!

    My Local Medicines Management Group States: -

    LMMG Process for Colour Classification of Medicines States: -

    Benefits to the patient

    In the interests of safety & patient convenience it is recommended that prescribing and monitoring of a medicine should be carried out by the same prescriber.

    Unlike most GP’s my GP was aware that Co-proxamol was the only analgesic that worked for me and continued to prescribe under the Named Patient scheme for seven years despite the pressures he was under from his insurers and MDS Union.

    Commissioning arrangements or inclusion of the medicine in a package of care.

    Medications should not be assigned a colour classification on the basis of costs,

    Unlicensed medicines and medicines which are used ‘off label’.
    These should generally be categorised as ‘Red’. (NOT BLACK)!

    Black list criteria

    Lack of effectiveness or safety data compared to standard therapy
    Increased side effects compared to standard therapy
    Lack of cost-effectiveness data compared to standard therapy
    NICE guidance which does not recommend use of the drug
    The medication is used to treat a condition which is not commissioned in Lancashire e.g. for cosmetic purposes (N.B commissioning policies may vary between CCGs)
    N.B. Recommendations made regarding colour classification are advisory. Where necessary primary and secondary care prescribers should discuss the management of individual patients. In addition where appropriate pathways are in place some CCGs may have a local variation.

    • November 2015 my GP informed me he could no longer prescribe Co-proxamol on the ‘Named Patient’ scheme. Within a month of the decision to end my prescription the recommended alternatives were once again causing me increasing unpleasant gastrointestinal side effects and not providing me with adequate pain relief resulting again in me having to lead a life of increased side effects, lack of sleep, and relentless debilitating pain.
    • I have gathered a huge amount of information regarding MHRA over the years in order to determine why MHRA wanted to eradicate a drug that had worked well for over fifty years. I finally came to this conclusion within the last month.

    As Co-proxamol had been on the market for over 50 years the income MHRA received from the 17 ‘Marketing Authorisation’ holders had diminished by 2005.

    My Questions to MHRA via FOI: - Co-proxamol, what was the monetary loss to MHRA when these MA’s were cancelled?
    MHRA response: - Zero

    What was the potential monetary loss to MHRA between 2008 and 2015? (Renewals Etc.)
    MHRA response: - This has been calculated to be approximately £100,000

    Alternate Analgesia
    How many MA’s were held for OXYCODONE drugs when the phased withdrawal for Co-proxamol was first announced
    in January 2005? 13
    How many MA’s were held in January 2015? 151

    What was the monetary Gain to MHRA between 2008 and 2015 resulting from any increases in the number of MA's issued? (Including Renewals Etc.).
    Approximately £1,550,000. This is the total received in application fees for these new marketing authorisations and does not include any subsequent licence variations or service fees.

    My attempt at obtaining an answer to the last question has been cunningly circumvented by them using Section 12 of the Freedom of Information Act. (Licence variations and service fees are a continuous flow of income for MHRA and are far more lucrative than the initial marketing authorisations)!

    MHRA’s reasoning for the removal of the MA’s was: - 300-400 deaths per year. Deaths from the alternate drugs have increased dramatically since the removal of co-proxamol!
    When the decision was made to remove the licence there were approximately 1.7 million patients taking Co-proxamol in the UK; the overdose death rate, assuming their figures were correct equated to just 0.02% OF PATIENTS WOULD HAVE BEEN AT RISK of death (intentional or accidental)!

    The vast majority of patients had taken Co-proxamol responsibly and, in normal use, CO-PROXAMOL POSED NO THREAT TO LIFE AND HAD CONSIDERABLY FEWER SIDE EFFECTS THAN ANY OTHER PAIN KILLING DRUG.
    Deaths in the UK from all of the alternate analgesia have increased alarmingly since the MA’s for Co-proxamol were removed!

    • Deaths from Tramadol rose from 53 in 2005 to 240 in 2014
    • Deaths from Oxycodone rose from 11 in 2005 to 53 in 2014
    • Deaths from Codeine rose from 44 in 2005 to 136 in 2014
    • Deaths from Fentanyl rose from 3 in 2005 to 40 in 2014
    • Deaths from Buprenorphine rose from 5 in 2005 to 24 in 2014
    THE ONLY BENEFIT OF BANNING CO-PROXAMOL HAS BEEN THE MANY MILLIONS OF POUNDS ADDED TO THE COFFERS OF MHRA!

    I have requested internal reviews for both of my FOI requests.
    MHRA Internal review received 14th November 2016 (FOI 16/546)
    https://www.whatdotheyknow.com/reque...ncoming-894810
    Blackpool CCG Internal review is overdue. (FOI-01520-Q1H3-BP)
    https://www.whatdotheyknow.com/reque...utgoing-587768

    Corruption @ MHRA
    https://mhracorrupt.st/

    https://www.theguardian.com/uk/2004/...ighereducation
    (First published on Saturday 13 March 2004 08.34 GMT)

    http://nsnbc.me/2013/07/28/uk-drug-s...for-6-million/ (Published On: Sun, Jul 28th, 2013)

  9. #9
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    thanks for your post I have been on co proximal after checking for at least 18 years the specialists that I have been under since 1988 to date have tried all manner of drugs on me the last being Hurima all do not seem to manage my conditions the co proximal is the only painkiller that works for me my G.P. is trying to get me off by allowing me only 4 per day which is a struggle I dont know about other users but when I take my co proxamol within 30 minutes the pain starts to diminish any way I am hoping to get them on a named patient basis soon

  10. #10
    Unfortunately your CCG will be determined to stop your GP from prescribing Co-proxamol because the drug has become too expensive. The reason for the price hike is simple to understand. The cost of the drug in 2004 was £2.70 per 100 tablets at that time there was 1.7 million patients in the UK receiving prescriptions and hundreds of millions of patients globally.

    During 2005 the UK Government accepted the CSM / MHRA's catastrophic recomendation to ban Co-proxamol from the end of 2007 this has resulted in worldwide misery! The UK’s initiative influenced the US Food and Drug Administration to take action in 2010 to withdraw Co-proxamol/Dextropropoxyphene) in the USA. Canada, Singapore, Taiwan, and New Zealand decided to take the same path. In December 2011 Australia also announced a decision to withdraw all analgesics containing dextropropoxyphene (Co-proxamol). However in April 2013 the AAT concluded that the quality, safety, and efficacy of Di-Gesic and Doloxene (Co-proxamol) were not unacceptable, provided that additional conditions and monitoring arrangements were imposed. The drug is now available for prescribing again in Australia. This has resulted in a worldwide shortage in dextropropoxyphene (the ingredient of Co-proxamol)

    During 2014 - 2015 the number of UK patients receiving Co-proxamol had fallen to below 60,00 and the price had increased again to £49.50 for 100 tablets. The only way I could receive Co-proxamol now would be on a private prescription at a cost of £130.00 for 100 tablets (my last quote from Boots chemist)

    Sign my petition here https://www.change.org/p/rt-hon-jere...icensed?utm_so
    Last edited by dlfteam; 23-12-16 at 09:51.

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